The following lists contain some of the key side effects that may occur while taking Plaquenil. If you have trouble sleeping or develop fatigue while you’re taking Plaquenil, talk with your doctor. If you have any skin changes while you’re taking Plaquenil, talk with your doctor right away. Skin rashes and pigment change. If you notice a change in your central or color vision or have trouble seeing at night, promptly schedule an evaluation with your eye doctor. The macula is also responsible for most of our color vision and it allows plaquenil reflux us to see fine detail. In the most serious cases of Plaquenil-induced retinal toxicity, the macula is completely destroyed. Ideally, you should have an eye exam before starting Plaquenil medication to get a “baseline” of your retinal health. Almost always the damage will go away if it is found early and the medicine stopped. Clinical examination and blood samples will be used for genetic testing and mutation identification.

Plaquenil works very slowly. Plaquenil changes the way your immune system works. Anti-malarial medications help to control lupus in several ways by modulating the immune system without predisposing you to infection. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system (your brain and spinal cord) and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. What are anti-malarial drugs, and why are they used to treat lupus? No fetal abnormalities are known to have occurred from taking hydroxychloroquine, and physicians at several major universities have used anti-malarial drugs for years to treat pregnant women with lupus without negative side effects on the fetus. Calculation of appropriate dose of hydroxychloroquine can minimize the risk of hydroxychloroquine retinopathy since vision loss is irreversible and there is no therapy to treat the resulting retinopathy. Anti-malarials can protect plaquenil severe rash against UV light and sometimes even improve skin lesions that do not respond sulfasalazine and plaquenil to treatment with topical therapy (ointments).

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